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Chimerigen
IL-21R (mouse):Fc (mouse) (rec.) (non-lytic)
Product Details | |
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Synonyms | Interleukin-21 Receptor; CD360; NILR |
Product Type | Protein |
Properties | |
Source/Host | CHO cells |
Sequence |
The extracellular domain of mouse IL-21R (aa 20-234) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a. |
Crossreactivity | Mouse |
Biological Activity |
Shows the biological function of the IL-21R moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. |
MW | ~50-100kDa |
Purity | ≥98% (SDS-PAGE) |
Endotoxin Content | <1EU/mg protein (LAL test; Lonza). |
Reconstitution | Reconstitute at 100μg/ml in sterile PBS. |
Formulation | Lyophilized from 0.2μm-filtered solution in PBS. |
Protein Negative Control | |
Other Product Data |
Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC). |
Declaration | Manufactured by Chimerigen. |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice |
Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. Complex formation between IL-21R and the common γ chain (γc) is required for signaling. IL-21R is expressed mainly on B cells (highest on mature, activated, follicular and germinal center B cells), NK cells and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells and keratinocytes. B cell IL-21R engagement induces Blimp1 (which mediates plasma cell differentiation) and is important for memory responses. IL-21R engagement on mouse NK cells enhances their cytotoxic activity and IFN-γ production. IL-21R engagement on CD8+ T cells aids control of viral infection and tumor growth; IL-21R is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation. IL-21R expression is often upregulated in allergic skin inflammation, systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL).